Effect of Cycloheximide on Unidirectional Sodium Fluxes in the Jejunum after Cholera Exotoxin Exposure
作者： David T. Grayer , Harold A. Serebro , Frank L. Iber , Thomas R. Hendrix
DOI: 10.1016/S0016-5085(70)80154-8
关键词: Exotoxin 、 Microbiology 、 Lumen (anatomy) 、 Flux (metallurgy) 、 Jejunum 、 Sodium 、 Biophysics 、 Biology 、 Cholera 、 Protein biosynthesis 、 Cycloheximide
摘要: Unidirectional fluxes of sodium were measured in jejunal loops rabbits exposed to cholera exotoxin. It was found that exotoxin caused an increased flux Na+ into the lumen, while out lumen not changed significantly. shown previously cycloheximide, inhibitor protein synthesis, prevents exotoxininduced fluid production by intestine. Measurement unidirectional demonstrated cycloheximide completely abolished exotoxin-induced increase loop significantly altering loop. is concluded intestinal solely blocking and water
gastrojournal.org
sci-hub.se 参考文章(16)
Harold P. Schedl, James A. Clifton, Ursula Winter, Donald White, Small intestinal absorption of steroids. Gastroenterology. ,vol. 41, pp. 491- 499 ,(1961) , 10.1016/S0016-5085(19)35095-4
William S. Hoffman, A RAPID PHOTOELECTRIC METHOD FOR THE DETERMINATION OF GLUCOSE IN BLOOD AND URINE Journal of Biological Chemistry. ,vol. 120, pp. 51- 55 ,(1937) , 10.1016/S0021-9258(18)74360-3
GM Fimognari, DD Fanestil, IS Edelman, Induction of RNA and protein synthesis in the action of aldosterone in the rat. American Journal of Physiology. ,vol. 213, pp. 954- 962 ,(1967) , 10.1152/AJPLEGACY.1967.213.4.954
Harold A. Serebro, Frank L. Iber, John H. Yardley, Thomas R. Hendrix, Inhibition of cholera toxin action in the rabbit by cycloheximide. Gastroenterology. ,vol. 56, pp. 506- 511 ,(1969) , 10.1016/S0016-5085(69)80159-9
W.R. Jondorf, D. Grünberger, Comparison of cycloheximide effect on hepatic protein synthesis at the microsomal level in vivo and in vitro Biochemical Pharmacology. ,vol. 16, pp. 2055- 2059 ,(1967) , 10.1016/0006-2952(67)90325-5
H. L. Ennis, M. Lubin, CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS. Science. ,vol. 146, pp. 1474- 1476 ,(1964) , 10.1126/SCIENCE.146.3650.1474
HAROLD A. SEREBRO, THEODORE M. BAYLESS, THOMAS R. HENDRIX, FRANK L. IBER, THOMAS MCGONAGLE, Absorption of d-Glucose by the Rabbit Jejunum during Cholera Toxin-induced Diarrhoea Nature. ,vol. 217, pp. 1272- 1273 ,(1968) , 10.1038/2171272A0
L.Lee Bennett, Virginia L. Ward, R.W. Brockman, Inhibition of protein synthesis in vitro by cycloheximide and related glutarimide antibiotics Biochimica et Biophysica Acta. ,vol. 103, pp. 478- 485 ,(1965) , 10.1016/0005-2787(65)90140-1
Felix O. Wettstein, Hans Noll, Sheldon Penman, Effect of cycloheximide on ribosomal aggregates engaged in protein synthesis in vitro Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. ,vol. 87, pp. 525- 528 ,(1964) , 10.1016/0926-6550(64)90131-8
I. S. Edelman, R. Bogoroch, G. A. Porter, ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 50, pp. 1169- 1177 ,(1963) , 10.1073/PNAS.50.6.1169