pRb2/p130 gene overexpression induces astrocyte differentiation.
作者： U. Galderisi , M.A.B. Melone , F.P. Jori , E. Piegari , G. Di Bernardo
关键词: Astrocyte 、 Cell growth 、 Population 、 Astrocyte differentiation 、 Cell 、 Biology 、 Apoptosis 、 Programmed cell death 、 Cell biology 、 Cell cycle checkpoint
摘要: Abstract There are many data on the activity of RB gene in neural differentiation and apoptosis, but role pRb2/p130 neuronal glial maturation has been far less investigated. To elucidate astrocyte development we overexpressed this protein astrocytoma normal cultures by adenoviral-mediated transfer. In cells, p130/RB2 overexpression resulted a significant reduction cell growth an increased G 0 /G 1 population. We did not observe any induction programmed death as determined TUNEL reaction. Interestingly, induced differentiation. Astrocyte cycle arrest seemed to proceed through way distinct from p53 pathway.
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