Overexpression of p21WAF1/CIP1 induces cell differentiation and growth inhibition in a human glioma cell line.
作者： Takashi Kokunai , Ichiro Izawa , Norihiko Tamaki
DOI: 10.1002/(SICI)1097-0215(19980209)75:4<643::AID-IJC24>3.0.CO;2-8
关键词:
摘要: p21 WAFI/CIPI is a downstream mediator of p53 and mediates growth arrest by inhibiting the action G 1 cyclin-dependent kinases. Since cellular differentiation frequently characterized arrest, we examined whether overexpression would induce suppression in p53-defective human glioma cells. Overexpression resulted an accumulation cells , altered morphology, cell differentiation. The extent correlated with level as well proliferating nuclear antigen, cyclin E, cdk 2, which associates . Our data suggest that gene transfer may vivo committing malignant to pathway terminal
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