Tumor Suppression by p21WAF1

摘要: Abstract The p21 WAF1 gene encodes a cyclin-dependent kinase inhibitor and mediates tumor suppressor p53 -induced cell cycle arrest. To directly test whether can act as suppressor, we have expressed the cDNA in several human lines using tetracycline-inducible system. Overexpression of suppresses proliferation soft agar growth cells vitro , well tumorigenicity vivo . Our data provide direct evidence for tumor-suppressive activity