Lung Function in Alpha1-Antitrypsin Heterozygotes (Pi Type MZ)1–3

摘要: Whether or not α1-antitrypsin heterozygotes are abnormally predisposed to lung disease is controversial. To define the pulmonary status of heterozygote Pi type MZ, results function studies performed in 54 adults MZ were compared those a control group 69 with MM. The had significantly inferior by following indices: arterial oxygen tension, elastic recoil, maximal expiratory flows, and closing capacity. lifetime nonsmokers lower tensions flows than MM nonsmokers. changes consistent early emphysema. Cigarette smoking interacted additively caused greater reduction either factor produced independently. It was concluded that significant risk disease.