Aromatase in human lung carcinoma.

摘要: Lung cancer is the leading cause of mortality in both women and men worldwide but gender differences exist their clinical biological manifestations. In particular, among life time non-smoker, female are far more likely to develop lung carcinoma than male. Recent studies demonstrated that estrogens synthesized situ male cancers through aromatase, suggesting sex steroid may contribute pathogenesis development carcinoma. addition, human carcinomas have been recently be frequently associated with expression estrogen receptors patients a lower aromatase was reported better prognosis. Preclinical further inhibitor (AI) suppressed tumor growth vitro vivo. These findings all suggest potential role intratumoral behavior non-small cell (NSCLC), most common form malignancy. Therefore, AIs become viable therapeutic options for disease management NSCLC definitely required obtain understanding roles as predictive biomarker outcome these patients.