Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies.

摘要: Background: Reproductive and hormonal factors are involved in the etiology of breast cancer, but there only a few prospective studies on endogenous sex hormone levels cancer risk. We reanalyzed worldwide data from to examine relationship between hormones risk postmenopausal women. Methods: analyzed individual nine 663 women who developed 1765 did not. None was taking exogenous when their blood collected determine levels. The relative risks (RRs) for associated with increasing concentrations were estimated by conditional logistic regression case–control sets matched within each study. Linear trends heterogeneity RRs assessed two-sided tests or chi-square tests, as appropriate. Results: increased statistically significantly all examined: total estradiol, free non-sex hormone-binding globulin (SHBG)-bound estradiol (which comprises albumin-bound estradiol), estrone, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone testosterone. quintiles concentrations, lowest quintile, 1.42 (95% confidence interval [CI] = 1.04 1.95), 1.21 CI 0.89 1.66), 1.80 1.33 2.43), 2.00 1.47 2.71; Ptrend<.001); 1.38 0.94 2.03), 1.84 1.24 2.74), 2.24 1.53 3.27), 2.58 1.76 3.78; Ptrend<.001). magnitudes other estrogens androgens similar. SHBG decrease (P trend .041). increases remained after subjects diagnosed 2 years collection excluded analysis. Conclusion: Levels strongly [J Natl Cancer Inst 2002;94:606–16]