Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

摘要: The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter development diet-induced obesity-diabetes and examined persistence beneficial metabolic effects in high fat ob/ob mice, respectively. Twice daily injection normal mice transferred a diet reduced energy intake (p < 0.001), body weight 0.01), circulating insulin LDL-cholesterol 0.001) improved sensitivity as well oral intraperitoneal glucose tolerance. Energy intake, weight, tolerance were similar lean controls. In addition, prevented effect feeding on triacylglycerol accumulation liver muscle. Interestingly, significantly elevated pancreatic glucagon content. Histological examination pancreata revealed no changes islet number or size, but there was increased turnover beta-cells with numbers peripherally located alpha-cells, co-expressing both GLP-1. Beneficial observed similarly treated twice for 18 days, including 0.05), 0.05 p 0.01) 0.05) 0.001). Notably, these still evident days following cessation treatment. These studies emphasize potential treatment obesity-diabetes.