deSUMOylation signaling: a novel mechanism of liver CSC properties and hepatocarcinogenesis in hypoxia

Adrian L. Harris, Hypoxia — a key regulatory factor in tumour growth Nature Reviews Cancer. ,vol. 2, pp. 38- 47 ,(2002) , 10.1038/NRC704

Ashutosh Kumar, Kam Y.J. Zhang, Advances in the development of SUMO specific protease (SENP) inhibitors Computational and structural biotechnology journal. ,vol. 13, pp. 204- 211 ,(2015) , 10.1016/J.CSBJ.2015.03.001

Prashant Sharma, Satoru Yamada, Margaret Lualdi, Mary Dasso, Michael R. Kuehn, Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo. Cell Reports. ,vol. 3, pp. 1640- 1650 ,(2013) , 10.1016/J.CELREP.2013.04.016

Jinke Cheng, Xunlei Kang, Sui Zhang, Edward T.H. Yeh, SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia Cell. ,vol. 131, pp. 584- 595 ,(2007) , 10.1016/J.CELL.2007.08.045

Chun-Hau Chen, Che-Chang Chang, Tae Ho Lee, ManLi Luo, Pengyu Huang, Pei-Hsin Liao, Shuo Wei, Fu-An Li, Ruey-Hwa Chen, Xiao Zhen Zhou, Hsiu-Ming Shih, Kun Ping Lu, SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function Cancer Research. ,vol. 73, pp. 3951- 3962 ,(2013) , 10.1158/0008-5472.CAN-12-4360

Jung Hwa Kim, Sung Hee Baek, Emerging roles of desumoylating enzymes Biochimica et Biophysica Acta. ,vol. 1792, pp. 155- 162 ,(2009) , 10.1016/J.BBADIS.2008.12.008

Avijit Majumdar, Steven A. Curley, Xifeng Wu, Powel Brown, Jessica P. Hwang, Kirti Shetty, Zhi-Xing Yao, Aiwu Ruth He, Shulin Li, Lior Katz, Patrizia Farci, Lopa Mishra, Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma Nature Reviews Gastroenterology & Hepatology. ,vol. 9, pp. 530- 538 ,(2012) , 10.1038/NRGASTRO.2012.114

Nabil Elrouby, Analysis of Small Ubiquitin-Like Modifier (SUMO) Targets Reflects the Essential Nature of Protein SUMOylation and Provides Insight to Elucidate the Role of SUMO in Plant Development Plant Physiology. ,vol. 169, pp. 1006- 1017 ,(2015) , 10.1104/PP.15.01014

Lan Shao, Huanjiao Jenny Zhou, Haifeng Zhang, Lingfeng Qin, John Hwa, Zhong Yun, Weidong Ji, Wang Min, SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression Nature Communications. ,vol. 6, pp. 8917- 8917 ,(2015) , 10.1038/NCOMMS9917

Chun-Ping Cui, Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Daniel Wai-Hung Ho, Eunice Yuen-Ting Lau, Yu-Man Tsui, Lo-Kong Chan, Tan-To Cheung, Kenneth Siu-Ho Chok, Albert CY Chan, Regina Cheuk-Lam Lo, Joyce Man-Fong Lee, Terence Kin-Wah Lee, Irene Oi Lin Ng, None, SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop Gut. ,vol. 66, pp. 2149- 2159 ,(2017) , 10.1136/GUTJNL-2016-313264