Thrombin generation in patients with a first acute myocardial infarction

摘要: Summary. Background: Despite improved treatment options, myocardial infarction is still an important cause of morbidity and mortality. One the contributing mechanisms in acute (AMI) plasma hypercoagulability. Methods: We investigated hypercoagulability 135 (first) patients with AMI using thrombin generation (TG) testing. TG testing was performed plasmas, drawn upon admission before medication administration, subsequently after 4 days, 3 6 months. Further, we evaluated determinants multiple regression analysis major coagulation proteins inhibitors. Admission results were also related to 1-year outcome: cardiovascular death, recurrent infarction, a second coronary intervention [percutaneous (PCI) or artery bypass grafting (CABG)] ischemic stroke. Results: At day 0, parameters peak height, endogenous potential (ETP) lag time increased compared reference population. Peak height stayed persistently patients. The lowest half ETP values statistically not significantly associated occurrence endpoints. combined upper D-dimer endpoints; odds ratio 5.8 (1.1–30.7). Tissue factor pathway inhibitor (TFPI) seems be determinant healthy persons. Conclusions: reflects during partly 6-month period event. shows trend inverse association risk complications. Unraveling might improve our understanding pathophysiology direct future improvements medical care.