Psychosis‐inducing effects of cannabis are related to both childhood abuse and COMT genotypes
作者： S. Alemany , B. Arias , M. Fatjó-Vilas , H. Villa , J. Moya
DOI: 10.1111/ACPS.12108
关键词: Psychiatry 、 Genotype 、 Allele 、 Comt gene 、 Psychology 、 Psychosis 、 Cannabis 、 Population 、 Childhood abuse 、 Effects of cannabis
摘要: Objective To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by COMT (catechol-O-methyltransferase) gene. Method Psychotic (PEs), Val158Met genotypes were assessed in 533 individuals from general population. Data analysed hierarchically means of multiple linear regression models. Results Childhood abuse showed a significant main effect on both positive (β = 0.09; SE = 0.04; P = 0.047) negative PEs (β = 0.11; SE = 0.05; P = 0.038). A three-way interaction found among gene (β = −0.30; SE = 0.11; P = 0.006). This result suggests that only influenced PE scores exposed to abuse. Furthermore, exposure increased Val carriers. However, but who did not cannabis, as function Met allele copies gene. Conclusion Cannabis after may have opposite effects risk PEs, depending providing evidence for qualitative interaction. carriers are vulnerable psychosis-inducing cannabis.
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