Decreased expression of programmed death 1 on peripheral blood lymphocytes disrupts immune homeostasis in peripartum cardiomyopathy

摘要: Peripartum cardiomyopathy (PPCM) is a disease of unknown pathogenesis. Programmed death 1 (PD1) has been postulated to modulate immune response through potential mechanisms that remain elusive. This study aimed elaborate the expression and function PD1 on peripheral blood lymphocytes (PBLs) in development PPCM. Specimens PBLs were performed determine mRNA using fluorescence quantitative RT-PCR, Th cytokines by ELISA. Immune homeostasis was evaluated with T lymphocyte phenotypes immunoglobulin (Ig) isotypes as well complement factors (C). Morphology observed transmission electronic microscope. Significantly elevated levels interferon (IFN)-γ, percentages CD3+, CD4+, CD8+ lymphocytes, pro-brain natriuretic peptide (BNP), but reduced interleukin (IL)-4, IgG, IgM, IgA, C3, C4, left ventricular ejection fraction (LVEF) detected, which associated significantly lower PPCM relative control. Furthermore, showed significant negative correlation IFN-γ proBNP positive IL-4, LVEF. The morphologic features cells indicated state activation. Therefore, decreased led LV dysfunction functional dysregulation costimulation cellular immunity. provided first findings decreased, might disrupt enhanced immunity predominant over attenuated humoral may work etiopathogenesis