Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer.

摘要: Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate development rational approaches for vaccine design, drug delivery, antagonizing immune suppression diagnostic imaging to treat effectively. Throughout last three decades, identification universal has failed due their complex carbohydrate polymer structures. Here, we focused on two types binding proteins or that may serve as AFPRs, namely, A) mucin family, B) scavenger family. We presented an informative review with detailed descriptions signal transduction, cross-talk, interplay various transcription factors which highlight downstream events following receptors. mainly explored underlying mechanisms involved interact AFP, provide more evidence support these tumor establish a theoretical basis targeting therapy cancer.