Differential atrophy of the lower-limb musculature during prolonged bed-rest.

摘要: Patients with medical, orthopaedic and surgical conditions are often assigned to bed-rest and/or immobilised in devices. Although such lead muscle atrophy, no studies have yet considered differential atrophy of the lower-limb musculature during inactivity enable development rehabilitative exercise programmes. Bed-rest is a model used simulate effects spaceflight physical inactivity. Ten male subjects underwent 56-days bed-rest. Magnetic resonance imaging lower-limbs was performed at 2-weekly intervals Volume individual muscles subsequently, rates were calculated. Rates differed (F = 7.4, p 0.081). Differential seen synergistic (e.g. adductor magnus > longus, 0.009; medial gastrocnemius lateral gastrocnemius, 0.002; vastii rectus femoris, 0.0002). These results demonstrate that imbalances can occur after extended periods reduced postural activity, potentially hampering recovery on return full upright body position. Such deconditioned patients should be prescribed "closed-chain" simulated resistance exercises, which target antigravity extensor most affected