Hyperphagia and depression-like behavior by adolescence social isolation in female rats.

摘要: This study was conducted to examine the effects of adolescence social isolation on food intake and psycho-emotional behaviors female rats. Female littermates were either single-caged (social isolation) or group-caged (control) from postnatal day 28, then subjected behavioral sessions during 50-53. Body weight gain isolates accelerated experimental period persistently greater than controls 35. Isolated females showed a selective increase in cookie when they had additional access standard chow. The exhibited hyperactivity with increased ambulatory counts rearings activity test as compared controls. Behavioral scores elevated plus maze did not differ between controls; however, immobility time forced swim significantly isolates. Basal levels plasma corticosterone elevated, but responding an acute stress blunted, ones. Results suggest that induces hyperphagia depression-like rats tonic may be implicated its underlying mechanisms.