Vitreal Pharmacokinetics of Peptide-Transporter-Targeted Prodrugs of Ganciclovir in Conscious Animals
作者： Kumar G Janoria , Sai HS Boddu , Subramanian Natesan , Ashim K Mitra , None
关键词: Ganciclovir 、 Intravitreal administration 、 Prodrug 、 Microdialysis 、 Pharmacology 、 Pharmacokinetics 、 Peptide 、 Dipeptide 、 Chemistry 、 Transporter 、 Ophthalmology 、 Pharmacology (medical)
摘要: Abstract Purpose: To delineate the vitreal pharmacokinetics of dipeptide monoester prodrugs ganciclovir (GCV) with conscious rabbit model using ocular microdialysis and to compare published results from anesthetized model. Methods: New Zealand albino male was selected as animal Conscious technique permanently implanted probes employed GCV, l-valine-GCV (Val-GCV), GCV [Val-Val l-glycine-Val (Gly-Val)] after intravitreal administration. Results: This work employs evaluate pharmacokinetic parameters compares previously data animal, thereby demonstrating effect anesthesia on disposition GCV. Results have revealed that area under curve (AUC), clearance, last measured plasma concentration (Clast) for all 4 compounds were significantly altered in a conscio...
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