Global Expression of Molecular Transporters in the Human Vaginal Tract: Implications for HIV Chemoprophylaxis
作者： Rebecca J. Nusbaum , Jignesh Patel , Kathleen L. Vincent , Charles Wang , Chao Guo
DOI: 10.1371/JOURNAL.PONE.0077340
关键词: Hiv transmission 、 Vagina 、 Human immunodeficiency virus (HIV) 、 Chemoprophylaxis 、 Young adult 、 Immunology 、 Transporter 、 ANTIRETROVIRAL AGENTS 、 Medicine 、 Drug disposition 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Pre-exposure chemoprophylaxis (PrECP) using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters human vaginal tract (VT) may play pivotal role determining drug disposition and, consequently, pharmacodynamic outcomes these efforts. Little known, however, on expression tissues, representing critical knowledge gap.
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