Changes in plasma levels of prekallikrein, kallikrein, high molecular weight kininogen and kallikrein inhibitors during lethal endotoxin shock in dogs.

摘要: Plasma levels of prekallikrein, kallikrein, high molecular weight kininogen and kallikrein inhibitors were measured in samples from dogs infused with E. coli endotoxin. Markedly reduced prekallikrein seen at circulatory collapse free was detected. Both ‘fast-reacting’ ‘time-dependent’ plasma significantly reduced. Fractionation pre-infusion by gel filtration together immunological procedures indicated that both α2-macroglobulin α1-antitrypsin the major dog plasma, they samples.