The values of synthetic substrates in the improvement of diagnostic tests for haemostatic function.

摘要: The accumulated evidence suggests that synthetic substrates measure a similar biological expression as their natural counterpart with, in some cases, better precision and simplicity of operation. Proteolytic enzymes are involved variety physiological pathological processes extending from blood coagulation to the release specific certain cells bacteria. variation level these proteases, inhibitors plasma or cells, will be an excellent indicator any malfunction particular system. Excellent agreement between new generation tests other conventional methods particularly measuring fibrinolytic components is seen, assay time cut hours matter minutes using reaction rate analyser. Some discrepancy estimated potency was observed used for thrombin, FVIII several clotting factors inhibitors. There has been methodological improvement and, cause revealed. Nevertheless, greater emphasis should still given standardization problems. It is, therefore, suggested until problems various resolved complications due non-specificity chromogenic non-selectivity overcome, ratio amidolytic activities included request estimations diagnostic assessment. Whether not use complementary supplementary left individual centres according circumstances.