Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response

摘要: Abstract Objective To determine the relative frequencies of signs in posterior segment ocular syphilis, response to a neurosyphilis regimen penicillin, and differences findings between human immunodeficiency virus (HIV)-coinfected -noncoinfected patients community setting. Design Retrospective, noncomparative, consecutive case series. Participants Fourteen with syphilis over 14-year period within or during acquired immune deficiency syndrome era. Intervention Neurosyphilis intravenous penicillin regimen. Main outcome measures Initial final visual acuity; treponemal nontreponemal serologic analyses; cerebrospinal fluid cell count, protein, Venereal Disease Research Laboratory signs; relapses recurrences. Results Blacks males were predominantly affected. Five (36%) HIV coinfected, led infection diagnosis three. Four (29%) had received previous antibiotic therapy for primary secondary raising suspicion relapse. Two negative results. All responded rapidly therapy. One patient subsequently relapsed after therapy, second was reinfected recurrence involvement. previously undescribed retinal manifestation discovered: sectorial retinochoroiditis delayed circulation involved area. Conclusions Ocular is form requires regardless when it develops infection. Conventional staging little use understanding syphilis. A high this appropriate, especially poorer black inflammatory disease. Human coinfection common, but does not affect short term. Awareness multiple presentations will aid ophthalmologists averting misdiagnosis diagnosis.