Method for treating tumors using anti-osteopontin antibodies

作者: Avi Ashkenazi , Robert Pitti , Thomas Wu , Zemin Zhang

DOI:

关键词: NanotechnologyCancer researchChemistryOsteopontinAntibody

摘要: The present invention is directed to compositions of matter useful for the treatment tumor in mammals and methods using those same.

参考文章(5)
Yasuyuki Yokosaki, Nobuchika Yamamoto, Masaki Noda, Yukihiko Saeki, Toshimitsu Uede, Shigeyuki Kon, Anti-osteopontin antibody and use thereof ,(2002)
C. Hota, A. F. Chambers, J. F. Harris, Jian-Wu Xuan, D. S. Bautista, Inhibition of Arg-Gly-Asp (RGD)-mediated cell adhesion to osteopontin by a monoclonal antibody against osteopontin. Journal of Biological Chemistry. ,vol. 269, pp. 23280- 23285 ,(1994) , 10.1016/S0021-9258(17)31650-2
Lucy Liaw, Donna M. Lombardi, Manuela M. Almeida, Stephen M. Schwartz, Denis deBlois, Cecilia M. Giachelli, Neutralizing Antibodies Directed Against Osteopontin Inhibit Rat Carotid Neointimal Thickening After Endothelial Denudation Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 17, pp. 188- 193 ,(1997) , 10.1161/01.ATV.17.1.188
Georg F Weber, The metastasis gene osteopontin: a candidate target for cancer therapy. Biochimica et Biophysica Acta. ,vol. 1552, pp. 61- 85 ,(2001) , 10.1016/S0304-419X(01)00037-3
R. A. Sikes, I. Klima, R. Markwalder, C. M. Farach-Carson, L. W. K. Chung, J. A. Kiefer, R. E. Devoll, U. E. Studer, George N. Thalmann, Osteopontin: Possible Role in Prostate Cancer Progression Clinical Cancer Research. ,vol. 5, pp. 2271- 2277 ,(1999)