Osteopontin functional epitopes, monoclonal antibodies against the epitopes and uses thereof
作者： Sheng Hou , Ling Peng , Jianxin Dai , Geng Kou , Weizhu Qian
DOI:
关键词: Osteopontin 、 Chemistry 、 Molecular biology 、 Monoclonal antibody 、 Nucleotide 、 Metastasis 、 Epitope
摘要: Provided are functional epitopes of osteopontin (OPN), monoclonal antibodies that specifically bind to the epitopes, immunoconjugates comprising and use or for manufacturing a medicament treatment tumor. Also provided nucleotide sequences encoding vectors host cells sequences. The can be used detecting OPN, blocking promoting metastasis-signaling pathway mediated by OPN preventing development metastasis tumor, thereby inhibiting
lens.org 参考文章(28)
Georg Weber, Osteopontin-based cancer therapies ,(2005)
Elvin A. Kabat, Sequences of proteins of immunological interest National Institutes of Health. ,(1991)
A. Miyauchi, J. Alvarez, E.M. Greenfield, A. Teti, M. Grano, S. Colucci, A. Zambonin-Zallone, F.P. Ross, S.L. Teitelbaum, D. Cheresh, Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. Journal of Biological Chemistry. ,vol. 266, pp. 20369- 20374 ,(1991) , 10.1016/S0021-9258(18)54932-2
Yasuyuki Yokosaki, Nobuchika Yamamoto, Masaki Noda, Yukihiko Saeki, Toshimitsu Uede, Shigeyuki Kon, Anti-osteopontin antibody and use thereof ,(2002)
Ah-Kau Ng, Lucy Liaw, Monoclonal antibodies against osteopontin ,(2007)
C. Hota, A. F. Chambers, J. F. Harris, Jian-Wu Xuan, D. S. Bautista, Inhibition of Arg-Gly-Asp (RGD)-mediated cell adhesion to osteopontin by a monoclonal antibody against osteopontin. Journal of Biological Chemistry. ,vol. 269, pp. 23280- 23285 ,(1994) , 10.1016/S0021-9258(17)31650-2
Alfonso R. Gennaro, Joseph P. Remington, Remington's pharmaceutical sciences Published in <b>1975</b> in Easton Pa) by Mack. ,(1985)
Avi Ashkenazi, Robert Pitti, Thomas Wu, Zemin Zhang, Method for treating tumors using anti-osteopontin antibodies ,(2004)
Shigeyuki Kon, Yasuyuki Yokosaki, Masahiro Maeda, Tatsuya Segawa, Yuko Horikoshi, Hiroe Tsukagoshi, Mohammod M. Rashid, Junko Morimoto, Manabu Inobe, Noriharu Shijubo, Ann F. Chambers, Toshimitsu Uede, Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences Journal of Cellular Biochemistry. ,vol. 84, pp. 420- 432 ,(2002) , 10.1002/JCB.10039
Hema Rangaswami, Anuradha Bulbule, Gopal C. Kundu, JNK1 Differentially Regulates Osteopontin-induced Nuclear Factorinducing Kinase/MEKK1-dependent Activating Protein-1-mediated Promatrix Metalloproteinase-9 Activation * Journal of Biological Chemistry. ,vol. 280, pp. 19381- 19392 ,(2005) , 10.1074/JBC.M414204200