Osteopontin-based cancer therapies

摘要: The invention relates to therapies for treating cancer patients by targeting the osteopontin isoforms OPN-b and OPN-c. Osteopontin is a cytokine that essential cellular immunity, particularly through its full length form, OPN-a. OPN-c are splice variants lack exons 5 4, respectively, of protein's six translated exons. provides methods with therapeutics inhibit or degrade specifically, thereby leaving innocuous OPN-a form intact available perform normal functions in cell.