Auditory Cortex Responsiveness During Talking and Listening: Early Illness Schizophrenia and Patients at Clinical High-Risk for Psychosis

摘要: Objective: The corollary discharge mechanism is theorized to dampen sensations resulting from our own actions and distinguish them environmental events. Deficits in this schizophrenia may contribute misperceptions of self-generated as originating external stimuli. We previously found attenuated speech-related suppression auditory cortex chronic patients, consistent with such deficits. Whether abnormality precedes psychosis onset, emerges early the illness, and/or progressively worsens illness chronicity, unknown. Methods: Event-related potentials (ERPs) were recorded patients (SZ; n = 75) age-matched healthy controls (HC; 77). A subsample (ESZ; 39) was compared at clinical high-risk for (CHR; 35) a subgroup HC (n 36) during Talk-Listen paradigm. N1 ERP component elicited by vocalizations subjects talked (Talk) heard played back (Listen). Results: As shown previously, SZ showed relative HC. This also observed ESZ. values CHR intermediate ESZ not statistically distinguishable either comparison group. Age-corrected difference z scores correlated duration full sample. Conclusions: Putative dysfunction speech evident stable over its course. effects reflect heterogeneity group, requiring longitudinal follow-up data address if abnormalities are risk marker conversion psychosis.