Alternative splicing of p53 and p73 : the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer
作者： G Hofstetter , A Berger , H Fiegl , N Slade , A Zorić
DOI: 10.1038/ONC.2009.482
关键词: Ovarian cancer 、 Cancer research 、 Exon 、 Alternative splicing 、 Biology 、 Intron 、 Hazard ratio 、 Tumor suppressor gene 、 Cancer 、 Carcinogenesis
摘要: Similar to p73, the tumor suppressor gene p53 is subject alternative splicing. Besides p53DeltaE6 and p53beta, we identified p53zeta, p53delta p53varepsilon, arising from splicing of exon 6 intron 9, respectively. splice variants were present in 18 34 ovarian cancer cell lines (52.9%) 134 245 primary cancers (54.7%). expression was associated with impaired response platinum-based chemotherapy (P=0.032). Also, constituted an independent prognostic marker for recurrence-free overall survival (hazard ratio 1.854, 95% confidence interval 1.121-3.065, P=0.016; hazard 1.937, 1.177-3.186, P=0.009, respectively). p53beta adverse clinicopathologic markers, that is, serous poorly differentiated (P=0.002 P=0.008, respectively), correlated worse patients exhibiting functionally active (P=0.049). DeltaN'p73 main N-terminally truncated p73 isoform preferentially found showing p53, supporting our hypothesis isoforms can alleviate selection pressure mutations by inhibition protein function.
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