Small airways dimensions in asthma and in chronic obstructive pulmonary disease.
作者： Kazuyoshi Kuwano , Carol H. Bosken , Peter D. Paré , Tony R. Bai , Barry R. Wiggs
DOI: 10.1164/AJRCCM/148.5.1220
关键词: Lung 、 Adventitia 、 Medicine 、 Submucosa 、 Pathology 、 Gastroenterology 、 Internal medicine 、 Peripheral 、 Small airways 、 Airway 、 Asthma 、 COPD
摘要: The purpose of this study was to compare the dimensions peripheral airways in fatal asthma with those from patients nonfatal asthma, mild COPD, and normal lung function. Lung specimens eight individuals who had asthmatic attacks were obtained at postmortem compared similar three died an unrelated cause four known required resection for tumor. These 15 lungs also resected neoplasms airway function (FEV1, % predicted > 85) chronic airflow obstruction < 85). All membranous a long-short diameter ratio 3:1 or less examined. smooth muscle tissue areas external internal layer traced using Bioquant BQ System 4. same system used evaluate fraction submucosa adventitia taken up by blood vessels. adventitial, submucosal, area greater than COPD control (p 0.01), 0.05). parameters 8 7 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
sci-hub.se 参考文章(15)
James C. Hogg, Rodrigo H. Moreno, Peter D. Paré, Mechanics of airway narrowing. The American review of respiratory disease. ,vol. 133, pp. 1171- 1180 ,(2015) , 10.1164/ARRD.1986.133.6.1171
Olive Jean Dunn, Virginia A Clark, Applied statistics: analysis of variance and regression (2nd ed.) John Wiley & Sons, Inc.. ,(1986)
P Hill, S E Webber, J G Widdicombe, D Goulding, Blood sinuses in the submucosa of the large airways of the sheep. Journal of Anatomy. ,vol. 162, pp. 235- 247 ,(1989)
Slatin Rc, Knudson Rj, Lebowitz, Burrows B, The maximal expiratory flow-volume curve. Normal standards, variability, and effects of age. The American review of respiratory disease. ,vol. 113, pp. 587- 600 ,(1976) , 10.1164/ARRD.1976.113.5.587
Nirmal B. Charan, John Butler, S. Lakshminarayan, Richard K. Albert, Wayne Kirk, Hypoxia and hypercarbia increase bronchial blood flow through bronchopulmonary anastomoses in anesthetized dogs. The American review of respiratory disease. ,vol. 134, pp. 89- 92 ,(1986) , 10.1164/ARRD.1986.134.1.89
B. R. Wiggs, C. Bosken, P. D. Paré, A. James, J. C. Hogg, A Model of Airway Narrowing in Asthma and in Chronic Obstructive Pulmonary Disease American Review of Respiratory Disease. ,vol. 145, pp. 1251- 1258 ,(1992) , 10.1164/AJRCCM/145.6.1251
Lauri A. Laitinen, M. Annika Laitinen, J.G. Widdicombe, Dose‐related effects of pharmacological mediators on tracheal vascular resistance in dogs British Journal of Pharmacology. ,vol. 92, pp. 703- 709 ,(1987) , 10.1111/J.1476-5381.1987.TB11374.X
Carol H. Bosken, Barry R. Wiggs, Peter D. Paré, James C. Hogg, Small airway dimensions in smokers with obstruction to airflow. The American review of respiratory disease. ,vol. 142, pp. 563- 570 ,(1990) , 10.1164/AJRCCM/142.3.563
Alan L. James, Peter D. Paré, James C. Hogg, The Mechanics of Airway Narrowing in Asthma The American review of respiratory disease. ,vol. 139, pp. 242- 246 ,(1989) , 10.1164/AJRCCM/139.1.242
Marc E. Csete, William M. Abraham, Adam Wanner, Vasomotion influences airflow in peripheral airways. The American review of respiratory disease. ,vol. 141, pp. 1409- 1413 ,(1990) , 10.1164/AJRCCM/141.6.1409