Carcinogenicity of Mutagens: Predictive Capability of the Salmonella Mutagenesis Assay for Rodent Carcinogenicity
作者： Errol Zeiger
DOI:
关键词: Carcinogen 、 Biology 、 Rodent carcinogenicity 、 Bacterial strain 、 Microbiology 、 Mutagen 、 Mutagenesis (molecular biology technique) 、 Predictive capability 、 Carcinogenesis 、 Toxicology 、 Salmonella
摘要: A total of 224 chemicals that have been tested in long-term studies for carcinogenicity rats and mice by the National Cancer Institute Toxicology Program were mutagenicity Salmonella typhimurium. Correlations between examined. The influences chemical structure, rodent species organ responses, bacterial strain responses on carcinogenesis/mutagenesis correlations also Not all carcinogens induced tumors both mice. clear mutagenic or equivocal response was predictive 77% carcinogens, although only 54% 149 mutagens, 58% nonmutagens carcinogens. proportion mutagens not carcinogenic 23%. There no apparent way to distinguish from noncarcinogens specific strains. proportions different classes data base strongly affected correlations; 40% chlorinated whereas 75% amines 100% nitro-containing mutagens. Because 29% (30% carcinogens) chlorinated, poor correlation this class reflected overall correlation. It is concluded use assay warranted identification but noncarcinogens. detected as dependent used define
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