Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine.

摘要: In rats, an ED50 for analgesia of morphine, meperidine, viminol R2 or azidomorphine decreases the turnover rate acetylcholine (TRACh) in cortex and hippocampus. These four analgetics fail to change TRACh striatum when given a dose range from ED30 up cataleptic dose. Viminol S2, nonanalgesic stereoisomer vimonol R2, fails decrease Naltrexone, opiate antagonist, also cortical hippocampal but it antagonizes elicited by analgetics. Since these which contains high density receptors intrinsic cholinergic neurons, hippocampus contain low receptors, can be inferred that are not exclusively involved regulation TRACh. However, results suggest certain pathways participate mediation analgesia.