PHARMACOLOGICAL IMPLICATIONS OF DOPAMINERGIC, CHOLINERGIC AND GABAERGIC NEURONS IN THE ACTION OF ANTIPSYCHOTICS AND NARCOTIC ANALGETICS

摘要: Abstract Opiates and antipsychotics increase the striatal turnover rate of dopamine. However, this biochemical change is not related to morphine analgesia because a dose haloperidol that causes no analgesia, increases The results obtained on two strains mice in which (DBA mice) locomotor activity (C57 are genetically differentiated demonstrate dopaminergic neurons mainly implicated response induced by morphine. On other hand, decrease acetylcholine cholinergic structures DBA proves might be involved analgesia. neurotransmitter interactions have been studied also describe profile action manifest different side-effects clinic studies. experiments show clozapine differ their dynamic GABA. These potential value order characterize biochemically drugs commonly used clinic.