In vivo actions of clozapine and haloperidol on the turnover rate of acetylcholine in rat striatum.
作者： G Racagni , M Trabucchi , D L Cheney , E Costa
DOI:
关键词: Apomorphine 、 Chemistry 、 Benztropine 、 Pharmacology 、 Acetylcholine 、 Haloperidol 、 Striatum 、 Antipsychotic 、 Clozapine 、 Oxotremorine
摘要: We have measured acetylcholine (ACh) content and turnover rate (TRACh) in striatum cortex of rats receiving haloperidol clozapine i.p. Both (30 mumol/kg) (10 reverse the decrease striatal TRACh elicited by apomorphine (11 while each antipsychotic affects steady state differently. Haloperidol fails to change ACh but increases TRACh; chozapine (15 30 neither decreases nor changes striatum. Moreover, 60 or 90 mumol/kg causes a 40% without affecting TRACh. Clozapine, not haloperidol, antagonizes increase arecoline (64 oxotremorine (9 Clozapine resembles trihexylphenidyl (14 benztropine (12 because it changing haloperidol. The could be value explain extrapyramidal action this drug. anticholinergic absence side effects observed with
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