Colistin Therapy in Infants and Children

摘要: COLISTIN, a polypeptide antibiotic derived from Aerobacillus colistinus , was introduced by Koyama in Japan the year 1950. 2 Gastrointestinal absorption is limited so that intramuscular injection required for systemic effect and this purpose sodium colistimethate (sodium colistin methanesulfonate) has been use United States. This drug shown to produce serum levels proportion administered dose 3 which are excess of those inhibition bactericidal upon many Gram-negative organisms vitro. 4 Most strains Pseudomonas, Escherichia coli paracolon, Klebsiella have demonstrated be sensitive tube dilution studies. 5 The toxicity older children adults, though variably reported, slight with no residual damage or death. 6 study reported herein devised an attempt determine whether methane sulfonate effective safe agent