Association between positive history of essential tremor and disease progression in patients with Parkinson's disease

摘要: This study aimed to explore the effect of pre-existing essential tremor (ET) history on disease progression Parkinson’s (PD). We recruited and followed-up a group PD patients from March 2009 July 2020. The ET each patient was obtained by retrospective interviews or past medical records. Cox proportional hazards models with inverse probability treatment weighting (IPTW) were used estimate hazard ratio (HR) 95% confidence intervals (CIs). Of 785 who completed visits, 61 (7.8%) reported ET. regression after IPTW indicated that positive in protective against time United Rating Scale III 14-point increase (HR = 0.301, CI = 0.134–0.678, P = 0.004), akinesia rigidity 8-point (HR = 0.417, CI = 0.218–0.796, P = 0.008), conversion Hoehn Yahr stage 3 (HR = 0.356, CI = 0.131–0.969, P = 0.043), develop dyskinesia (HR = 0.160, CI = 0.037–0.698, P = 0.015), Montreal Cognitive Assessment 3-point decrease (HR = 0.389, CI = 0.160–0.946, P = 0.037), but had no relationship 4-point (HR = 1.638, CI = 0.822–3.266, P = 0.161) death (HR = 0.713, CI = 0.219–2.319, P = 0.574). Our that ET is associated benign prognosis slower motor non-motor progression.