Imidazole compounds, their preparation and use

摘要: The present invention discloses compounds of the formula wherein X is C or N; Y R11 hydrogen, hydroxy, alkoxy; R12 and R13 are each independently hydrogen; halogen; CF3; CN; OH; alkyl;cycloalkyl; cycloalkylalkyl; alkenyl; alkynyl; phenylalkyl; amino; nitro;sulphamoyl; pipiridyl; pyrrolldinyl; acyl; CO2H; CO2-alkyl; CO-amino; NH-CO-alkyl;phenylsulphonyl which may be substituted with CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, nitro; phenyloxy halogen, phenylamino aryl one more times cycloalkyl, cycloalkylalkyl, phenoxy, phenylalkyl, nitro, sulphamoyl, pipiridyl, pyrrolidinyl, CO2H, CO-amino, NH-CO-alkyl; R4, R5, R6 R7 nitro;CN; COOH; COO-alkyl; alkyl; -(CH2)n,-OH n 0, 1,2, 3;-(CH2)m-O-alkyl m 3; -(CH2)o-O-acyl o 3;and that if N then R4 absent absent;or a pharmaceutically-acceptable addition salt thereof useful as pharmaceuticals, for example, in treatment stroke, ischemia, anoxia, migraine psychosis.