Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells.
作者： Shuji Hasegawa , Ken Taniguchi , Akira Yokomizo , Takashi Kuwano , Mayumi Ono
关键词: Multiple drug resistance 、 Etoposide 、 Drug resistance 、 Gene expression 、 Vincristine 、 Cancer research 、 Doxorubicin 、 P-glycoprotein 、 Biology 、 Glioma
摘要: The multidrug-resistance phenotype in human tumors is partly associated with over-expression of the 170 kDa-P-glycoprotein encoded by multidrug-resistance-1 (MDR1) gene. Another related, but non-P-glycoprotein, multidrug-resistance-associated protein (MRP) gene encodes a 190 kDa-membrane ATP-binding protein. Glioblastoma multiforme highly malignant primary neoplasm central nervous system which refractory to anti-cancer chemotherapy, mechanism underlying this drug resistance unknown. Out glioma cell lines, 2, namely IN500 and T98G, had elevated MRP mRNA levels, showed highest multiple agents such as etoposide, vincristine adriamycin, decreased intracellular accumulation etoposide. In remaining 5 various degrees sensitivity adriamycin etoposide appeared correlate their respective levels. Our study proposes that may be involved spontaneous multidrug gliomas.
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