Association between melatonin receptor 1A ( MTNR1A ) gene single-nucleotide polymorphisms and the velvet antler yield of Sika deer
作者： Fei-Fei Yang , Li-Jun Huo , Li-Guo Yang , Hasan Riaz , Li-Rong Xiong
DOI: 10.1007/S11033-013-2883-X
关键词: Genotype 、 Melatonin receptor 1A 、 Velvet antler 、 Allele frequency 、 Genetics 、 Locus (genetics) 、 Single-nucleotide polymorphism 、 Biology 、 Antler 、 Restriction fragment length polymorphism
摘要: Melatonin, a secretion from pineal gland is ambiguously considered as the key hormone involved in regulation of antler cycle Sika deer. To find out more about roles melatonin and its receptor gene, we carried current study to investigate association between polymorphisms 1A (MTNR1A) gene yield A total 251 deer were analyzed this study, which consisted Wusan (n = 163) Dongfeng 88). MTNRA was amplified by PCR genotyped Polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Three loci (C518T, C629G C635T) detected exon2 MTNR1A gene. The restriction site Ecol881 used for C518T while locus digested with Mval endonucleases. In allele frequencies C T 0.637 0.363 C518T, Also G alleles 0.206 0.794. Genotypic CC, CT TT 33.7, 59.9 6.4 % respectively, It showed 1.8, 37.4 60.7 genotypes CG GG. 0.518 0.482 0.375 0.625 C629G. 10.6, 82.4 7.1 they 1.1, 72.7 26.2 Among three SNPs, only significant (P < 0.05) average deer, no SNP These preliminary results implied that identified SNPs might influence
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