ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs.
作者： Christopher R. LaPensee , Jacqueline E. Mann , William E. Rainey , Valentina Crudo , Stephen W. Hunt
DOI: 10.1210/EN.2015-2052
关键词: Internal medicine 、 Sterol O-acyltransferase 、 Programmed cell death 、 Biology 、 Acyltransferase 、 Endocrinology 、 Endoplasmic reticulum 、 Unfolded protein response 、 Adrenocortical carcinoma 、 Apoptosis 、 Adrenal cortex
摘要: … Lentiviral small hairpin ribonucleic acid (shRNA) technology (Dharmacon); ACAT1 (SOAT1 in humans) (V2LHS_153311) ATAAGAAGTACAAATACTG. Lentiviral … were transfected into …
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sci-hub.se 参考文章(55)
L Liscum, J R Faust, The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one. Journal of Biological Chemistry. ,vol. 264, pp. 11796- 11806 ,(1989) , 10.1016/S0021-9258(18)80136-3
Y. Lange, Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. Journal of Biological Chemistry. ,vol. 269, pp. 3411- 3414 ,(1994) , 10.1016/S0021-9258(17)41877-1
Lawrence L. Rudel, Kelly A. Skinner, Matthew A. Davis, Mark C. Willingham, Richard G. Lee, Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates Journal of Lipid Research. ,vol. 41, pp. 1991- 2001 ,(2000) , 10.1016/S0022-2275(20)32360-9
V Meiner, C Tam, M D Gunn, L M Dong, K H Weisgraber, S Novak, H M Myers, S K Erickson, R V Farese, Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. Journal of Lipid Research. ,vol. 38, pp. 1928- 1933 ,(1997) , 10.1016/S0022-2275(20)37168-6
Carlos Leon, John S. Hill, Kishor M. Wasan, Potential Role of Acyl-Coenzyme A:Cholesterol Transferase (ACAT) Inhibitors as Hypolipidemic and Antiatherosclerosis Drugs Pharmaceutical Research. ,vol. 22, pp. 1578- 1588 ,(2005) , 10.1007/S11095-005-6306-0
Drago R. Sliskovic, Brian R. Krause, Joseph A. Picard, Maureen Anderson, Richard F. Bousley, Katherine L. Hamelehle, Reynold Homan, Thomas N. Julian, Zara A. Rashidbaigi, Richard L. Stanfield, Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity. Journal of Medicinal Chemistry. ,vol. 37, pp. 560- 562 ,(1994) , 10.1021/JM00031A002
Grushenka H.I Wolfgang, John R Macdonald, Laurence A Vernetti, David G Pegg, Donald G Robertson, Biochemical alterations in guinea pig adrenal cortex following administration of PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase. Life Sciences. ,vol. 56, pp. 1089- 1093 ,(1995) , 10.1016/0024-3205(95)00045-8
Wah-Seng Lim, Jenelle M. Timmins, Tracie A. Seimon, Anthony Sadler, Frank D. Kolodgie, Renu Virmani, Ira Tabas, Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo Circulation. ,vol. 117, pp. 940- 951 ,(2008) , 10.1161/CIRCULATIONAHA.107.711275
Hiderou Yoshida, Toshie Matsui, Akira Yamamoto, Tetsuya Okada, Kazutoshi Mori, XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Cell. ,vol. 107, pp. 881- 891 ,(2001) , 10.1016/S0092-8674(01)00611-0
Frederick R. Maxfield, Ira Tabas, Role of cholesterol and lipid organization in disease Nature. ,vol. 438, pp. 612- 621 ,(2005) , 10.1038/NATURE04399