Potential Role of Acyl-Coenzyme A:Cholesterol Transferase (ACAT) Inhibitors as Hypolipidemic and Antiatherosclerosis Drugs
作者： Carlos Leon , John S. Hill , Kishor M. Wasan
DOI: 10.1007/S11095-005-6306-0
关键词: Reverse cholesterol transport 、 Apolipoprotein E 、 Cholesterol 7 alpha-hydroxylase 、 Cholesteryl ester 、 Biochemistry 、 Sterol O-acyltransferase 、 Chemistry 、 Cholesterol 、 Internal medicine 、 Endocrinology 、 Intermediate-density lipoprotein 、 Very low-density lipoprotein
摘要: Acyl-coenzyme A:cholesterol transferase (ACAT) is an integral membrane protein localized in the endoplasmic reticulum. ACAT catalyzes formation of cholesteryl esters from cholesterol and fatty acyl coenzyme A. The are stored as cytoplasmic lipid droplets inside cell. This process very important to organism high levels have been associated with cardiovascular disease. In mammals, two genes identified, ACAT1 ACAT2. ubiquitous responsible for ester brain, adrenal glands, macrophages, kidneys. ACAT2 expressed liver intestine. inhibition activity has decreased plasma by suppressing absorption diminishing assembly secretion apolipoprotein B-containing lipoproteins such low density lipoprotein (VLDL). also prevents conversion macrophages into foam cells arterial walls, a critical event development atherosclerosis. review paper will focus on role metabolism, particular target develop novel therapeutic agents control hypercholesterolemia, atherosclerosis, Alzheimer's
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