Acyl-coenzyme A:cholesterol acyltransferase inhibitors for controlling hypercholesterolemia and atherosclerosis.

摘要: Abstract Acyl-coenzyme A:cholesterol acyltransferase (ACAT; Sterol O-acyltransferase/SOAT) is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-coenzyme A. ACAT inhibitors reduce plasma levels by suppressing absorption dietary assembly secretion apolipoprotein B-containing lipoproteins such as very low density lipoprotein in liver chylomicron intestine. Moreover, prevent conversion macrophages into foam cells arterial walls. Thus, are under investigation for controlling hypercholesterolemia development atherosclerosis. Some potent have been tested their efficacy safety humans.