Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula

摘要: Background and Purpose—Stroke neurodegeneration cause significant brain damage cognitive impairment, especially if the insular cortex is compromised. This study explores for first time whether these 2 causes differentially alter connectivity patterns in cortex. Methods—Resting state–functional magnetic resonance imaging data were collected from patients with stroke, behavioral variant frontotemporal dementia, healthy controls. Data 3 groups assessed through a correlation function analysis. Specifically, we compared decreases as of voxel Euclidean distance within Results—Relative to controls, stroke showed faster decays (hypoconnectivity). In contrast, dementia group exhibited hyperconnectivity between neighboring voxels. Both patient evinced global hypoconnectivity. No between-group diffe...