Circulating auto-antibodies in Ménière's disease.

摘要: In the last years, it has been claimed that patients suffering from Meniere's disease exhibit Circulating Immune Complexes, as well free antibodies specifically directed against type II collagen, a component of mammal inner ear. Furthermore, by means repeated injections collagen to guinea-pig. reproduced. Taken together, all these features strongly suggest fulfills most postulates Witebsky established for classification auto-immune diseases. However, in spite being very known marker conditions, non organ nor species specific Auto-Antibodies (CAA) have not reported, our knowledge, disease. Based upon this fact, Anti-Nuclear, Anti-Mitochondrial, Anti-Smooth Muscle, Anti-LKM and Anti-Parietal Gastric Cells investigated 49 diagnosed having according criteria AAOO. All them were asymptomatic at time study. Seventy eight serum samples Normal Healthy Subjects (NHS) constituted control group. CAA tested indirect immunofluorescence on rat organs method described Coons. Additionally, seric levels C3, C4 haemolytic capacity (CH-50) tested. Complexes (CIC) Complement-Mediated Mechanisms involved clearance CIC (Complement-Mediated Solubilization Inhibition Precipitation) parallel.(ABSTRACT TRUNCATED AT 250 WORDS)