Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate

摘要: Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of still unclear. In this study, we evaluated autoimmunity a potential cause disease. addition tried to find useful biomarker candidates for diagnosis. We investigated protein composition human fluid using liquid column mass spectrometry, autoimmune reaction between circulating autoantibodies in patient serum multiple antigens Protoarray system, immune mouse tissues western blot analysis. Nine proteins, including immunoglobulin its variants interferon regulatory factor 7, were found only patients with Enhanced reactions 18 candidate detected analysis; levels 8 these more than 10-fold higher controls. Antigen-antibody proteins molecular weights 23–48 kDa 63–75 sera patients. These findings suggest could be one mechanisms behind Multiple may involved reaction. Specific caused patient's analysis diagnostic biomarkers