Impact of a clinical trials information handbook on patient knowledge, perceptions, and likelihood of participation.

摘要: If evidence-based medicine is the backbone of modern medical practice, clinical trial results are vertebrae. Appropriately designed randomized trials provide valid assessments safety and efficacy treatments, diagnostics, preventive therapies. Thus, can influence mainstream change practice.' Yet an impediment to research low number individuals who enroll in trials. One barrier enrollment negative public perceptions about with humans, e.g., Nazi experiments during World War II U.S. Public Health Service's syphilis study Tuskegee, Alabama, that damaged reputation human subjects among a substantial segment population.' These have been reinforced by recent disclosures ethical lapses research.3 Other barriers include public's lack understanding methods purposes institutional safeguards incorporated into process protect participants.4 Accusations alleged abuses well-publicized, but diligent work