Modified oncolytic vaccinia virus
作者： Vincenzo Cerullo , Akseli Hemminki , Eerika Karli , Markus Vähä-Koskela , Julia Diaconu
DOI:
关键词: Virology 、 Thymidine Kinase Gene 、 Gene 、 Adjuvant 、 Oncolytic virus 、 Virus 、 Vaccinia growth factor 、 Biology 、 Cancer 、 Vaccinia
摘要: The invention relates to modified oncolytic vaccinia virus vectors and their uses in cancer therapy. comprise inactivating mutations the thymidine kinase gene growth factor addition genes encoding marker or adjuvant proteins. A production method for inventive construct is also disclosed. are useful systemic sequential therapeutic use cancer.
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