Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages
作者： Sang-Bae Han , Jae Kwon Lee
DOI: 10.1007/S12272-009-1418-4
关键词: Cell culture 、 Interleukin 、 Molecular biology 、 Proinflammatory cytokine 、 Cancer research 、 Histone deacetylase 、 Tumor necrosis factor alpha 、 Trichostatin A 、 Histone deacetylase inhibitor 、 Cytokine 、 Chemistry 、 Organic chemistry 、 Molecular medicine 、 Drug discovery
摘要: Histone deacetylase (HDAC) inhibitors were recently shown to suppress inflammatory responses in models of autoimmune and diseases. In this study, the anti-inflammatory effects five different HDAC on lipopolysaccharide-(LPS)-stimulated macrophages compared mechanisms these demonstrated. Trichostatin-A (TSA) scriptaid, two inhibitors, showed most potent inhibitory nitric-oxide (NO) production RAW264.7 cells bone-marrow-derived (BMDMs). TSA significantly decreased mRNA protein levels proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, whereas pretreatment with increased level immunosuppressive cytokine IL-10. also reduced cell surface markers maturity macrophages. Furthermore, a longer duration (up 8 h) hyperacetylation was observed that had been exposed TSA, induced by other absent after h. These results demonstrated is inhibitor histone deacetylation has greatest ability induce activity cloned naive are expected serve guide for future studies inhibit acute chronic
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