Thromboembolic events after aortic valve replacement in elderly patients with a Carpentier-Edwards Perimount pericardial bioprosthesis

摘要: Abstract Objectives Thromboembolic events after aortic valve replacement with a bioprosthesis were the most frequently occurring complications in elderly patients. Whether this was related or dependent on other factors needed further exploration. Methods Five hundred patients median age of 73 years followed retrospectively pericardial prosthesis for occurrence thromboembolism. Of these, 348 also underwent coronary artery bypass grafting. Twenty-five investigated their potential effect by using univariate and multivariate analysis. Results Univariate analysis revealed 6 significant factors: preoperative endocarditis ( P = .0001), cerebrovascular accident .002), use postoperative warfarin sodium (Coumadin, DuPont Merck; .006), arterial hypertension .023), size 27 mm larger hospital thromboembolism .040). There trend toward increased fatal without medication. With analysis, 4 remained significant: (risk ratio, 4.8; .0016), 3.0; .0028), 5.6; 6.1; .016). Hypertension had borderline effect. Age, sex, diabetes, factors, 3 valvular atrial fibrillation, carotid disease no Conclusions Some emboli seemed triggered prosthesis. A proper anticoagulant protocol but treatment is important prevention bioprosthesis. We did not find role fibrillation disease.