A Simple Method for the Electrophilic Cyanation of Secondary Amines
作者： Chen Zhu , Ji-Bao Xia , Chuo Chen
DOI: 10.1021/OL403245R
关键词: Electrophile 、 Cyanation 、 Cyanogen 、 Halide 、 Amine gas treating 、 Reagent 、 Nucleophile 、 Chemistry 、 Organic chemistry 、 Trimethylsilyl cyanide
摘要: Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.
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