Extracorporeal bubbles: a word of caution.

摘要: Objectives Gaseous microemboli (GME) are a cause of neurocognitive deficit postcardiac surgery with cardiopulmonary bypass. However, the measurement microbubbles during bypass is not easy, because blood an opaque fluid and contains microparticles. Recently, two new microbubble counters, Gampt BC200 emboli detection classification (EDAC) quantifier, were developed for use cardiac surgery. The accuracy both devices was validated against industrial standards. Methods A clear analogue (30%/70% glycerol-water) pumped, by means rollerpump out partially filled arterial line screen filter nominal pore size 20 microm. Downstream pump, all test sensors optical cuvette, inserted in vertically mounted 3/8 inch tubing. Measurements taken at flows 405, 1080, 3000 6000 ml/min. Backlight shadowgraphy counting used as reference techniques measuring counts. Results On average EDAC quantifier underestimates bubble diameter 35+/-1%, 13+/-8%, 71+/-7% 33+/-4% ml/min, respectively. has good sizing agreement 1080 ml/min (+5+/-17%) (+33+/-6%) but overestimates 220+/-40% 295+/-49% 405 Both only count number higher flows. At 3 l/min counts 38%, 18% total 6 3% Conclusions can be clinical setting monitoring basal GME production. have some major limitations when studying 'worst case' scenarios. One should take great caution correlating measured data outcome. Finally, results obtained one device first study cannot compared nor exchanged from other second study.