Left atrial function assessed by speckle tracking echocardiography as a predictor of new-onset non-valvular atrial fibrillation: results from a prospective study in 580 adults

作者: T. Hirose , M. Kawasaki , R. Tanaka , K. Ono , T. Watanabe

DOI: 10.1093/EJECHOCARD/JER251

关键词: Atrium (architecture)MedicineCardiologyPredictive value of testsAtrial fibrillationSpeckle tracking echocardiographyArea under the curveInternal medicineProspective cohort studyLogistic regressionReceiver operating characteristic

摘要: Aims The aim of this prospective study was to evaluate left atrial (LA) function for the prediction increased risk new-onset non-valvular fibrillation (AF). Risk stratification AF based on LA remodelling may have a major public health impact. Although volume (LAV) or dimension been proposed as predictors AF, other predictive parameters not yet fully examined. Methods and results emptying (EF), strain rate (SR), LAV were evaluated in apical four-chamber view by speckle tracking echocardiography 580 consecutive adults (age 64 ± 17, 303 men) without history arrhythmias. During follow-up period 28 months, 32 subjects 73 9, 18 developed electrocardiographically confirmed AF. Subjects with had lower active EF (16 5 vs. 8%, P < 0.001) SR at contraction (−0.9 0.2 −1.4 0.5 S−1, 0.001), but larger maximum index (59 12 46 16 mL/m2, compared non-AF baseline. In multivariate logistic regression analysis, only independent predictor Using an cut-off ≤20%, sensitivity specificity receiver operator characteristic curve analysis 88 81%, respectively (area under curve: 0.92). Conclusion Reduced (booster pump function) assessed independently predicts suggesting stronger association between functional than size

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