Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review.

摘要: The purpose of this review was to identify the relationship between gut microbiome and development postoperative complications like anastomotic leakage or a wound infection. Recent reviews focusing on underlying molecular biology suggested that might be influenced by patients’ flora. Therefore, available clinical data is needed. In January 2017 systematic search carried out in Medline WebOfScience all studies, which investigated after gastrointestinal surgery relation gut. Of 337 results 10 studies were included into analysis checking for eligibility. total, comprised 677 patients. All reported change five amount bacteria decreased different degrees surgery, but only one study found significant reduction. Surgical procedures tended result an increase potentially pathogenic decrease Lactobacilli Bifidobacteria. rate infectious lower patients treated with probiotics/symbiotics compared control groups without clear systemic inflammatory response. treatment synbiotics/probiotics addition resulted faster recovery bowel movement diarrhea abdominal cramping. There flora complications. Due methodological shortcomings uncontrolled bias/confounding factors there remains high level uncertainty.