Perioperative synbiotic therapy in elderly patients undergoing gastroenterological surgery: A prospective, randomized control trial

摘要: Abstract Objective Enteral administration of synbiotics has been reported to be beneficial during various types surgery, but its clinical value in elderly surgical patients remains unclear. The aim this study was quantitatively evaluate the changes gut microbiota and environment induced by perioperative synbiotic therapy, investigate whether it is possible reduce infectious complications undergoing gastroenterological surgery. Methods Forty-eight over age 70 y were randomized into a group receiving 7 d preoperative 10 postoperative therapy (S group) control without (C group). A fecal sample collected before after surgery each used for quantitative evaluation microbiota. Results completed trial (25 S 23 C Synbiotic significantly maintained status Bifidobacterium Lactobacillus , whereas number Enterobacteriaceae Staphylococcus, Pseudomonas decreased. total organic acid short-chain fatty concentrations increased, pH markedly decreased, compared with group. incidence 12% 36% group, however, difference did not reach statistical significance ( P = 0.06). multivariate analysis revealed that only use blood transfusion an independent risk factor complications. Conclusions improved intestinal microbial environment, might decrease patients.